Module: Lysis

For large DNA phages, host cell lysis is an active genetically programmed pathway that releases phages from the infected cell into the environment. Lysis is independent of virion assembly and involves targeted disruption of the cell envelope layers.

i-spanin Description:

Inner membrane subunit of the two-component spanin system. Encodes a transmembrane domain that anchors it in the host inner membrane. The i-spanin is involved in outer membrane disruption during host cell lysis by phage.

Protein Function

i-spanin

paired bimolecular spanin: p0034

spanin type: OVERLAP